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長庚大學 生化與生醫工程研究所
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2017-05-12

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蔡曉雯

蔡曉雯 Shiao-Wen Tsai 教授

學( 經 )歷:

國立陽明大學博士

專        長:

生醫材料、組織工程、奈米材料生醫應用

研 究 成  果: 期刊論文及專利等

分        機:

5984

實   驗   室:

生醫材料與組織工程實驗室(工學大樓9樓)

e-mail:

swtsai@mail.cgu.edu.tw  

學歷

陽明大學                

醫學工程博士     

1993/09-1999/06

清華大學

化學工程學士

1988/09-1992/06

經歷

長庚大學生化與生醫研究所

教授 2015/08-

長庚大學生化與生醫研究所

副教授

2007/08-2015/07

長庚大學生化與生醫研究所

助理教授

2002/08-2007/07

工業材料技術研究院生物醫學中心

研究員

2000/06-2002/07

澳洲Commonwealth Scientific and Industrial Research Organization Molecular Science

訪問學者

2001/03-2001/07

國立陽明大學醫學工程研究所

博士後研究員

1999/08-2000/05

研究領域

生醫高分子材料的研發

主要研究探討複合生醫高分子材料合成、修飾及定性,以及材料與組織細胞間的相容,質量傳輸現象等等。以期提供一個類似生物體內的環境應用於體外培養細胞,甚至可促進組織細胞的再生修復功能,以作為組織再生之基質應用開發。


釋放控制載體材料之研發與製備

生長因子適時適地的刺激,可以幫助細胞表現其特定生理表徵。因此,應用微粒之製備技術以及材料的特性,針對特定的細胞、組織對生長因子的個別需求,調控其可 在不同的生長時間點,釋放相關之生長因子,並評估其協助組織再生、重組(remolding之效能。此技術另可應用於細胞、 藥物之包覆,作為人工臟器或藥物制放相關之基材。

著作目錄

期刊論文

Ø   Lin CE, Rau LR, Liaw JW, Hsu FY, Tsai SW*Biocompatibility analysis of NIH/3T3 cells exposed to silica-coated silver and silver nanoparticles. Nanoscience and Nanotechnology Letters. 8:1080–1088. 2016.

Ø   Rau LR, Huang WY, Liaw JW, Tsai SW*. Photothermal effects of laser-activated surface plasmonic gold nanoparticles on the apoptosis and osteogenesis of osteoblast-like cells. International Journal of Nanomedicine. 11: 3461–3473. 2016.

Ø   Rau LR, Tsao SW, Liaw JW, Tsai SW*. Selective Targeting and Restrictive Damage for Nonspecific Cells by Pulsed Laser-Activated Hyaluronan-Gold Nanoparticles. Biomacromolecules. 17:2514-2521. 2016.

Ø   Tsai SW, Chang YH, Yu JL, Hsu HW, Rau LR, Hsu FY. Preparation of Nanofibrous Structure of Mesoporous Bioactive Glass Microbeads for Biomedical Applications. Materials. 9:487. 2016. Doi:10.3390/ma9060487.

Ø   Lee CY, Lei K, Tsai SW, Tsang NM. Development of Graphene-based Sensors on Paper Substrate for the Measurement of pH Value of Analyte. BioChip Journal. DOI 10.1007/s13206-016-0304-7. 2016.

Ø   Hsu HT, Rau LR, Zeng YN, Kang YL, Tsai SW*, Wu MH. External vibration enhances macromolecular crowding for construction of aligned three-dimensional collagen fibril scaffolds. Biofabrication. 7: 025004. 2015.

Ø   Yu SY, Tsai SW, Chen YJ, Liaw JW. Pulsed laser induced microbubble in gold nanorod colloid. Microelectronic Engineering 138:102–106. 2015.

Ø   Lei KF, Yang SI, Tsai SW, Hsu HT. Paper-based microfluidic sensing device for label-free immunoassay demonstrated by biotin–avidin binding interaction. Talanta. 134:264–270. 2015.

Ø   Huang SB, Chang YH, Lee HC, Tsai SW, Wu MH. 2014. A pneumatically-driven microfluidic system for size-tunable generation of uniform cell-encapsulating collagen microbeads with the ultrastructure similar to native collagen. Biomedical Microdevices.1-10.

Ø   Tsai SW, Huang CC, Rau LR, Hsu FY. 2014. Fabrication of aligned carbon nanotube/ polycaprolactone/gelatin nanofibrous matrices for Schwann cell immobilization. Journal of Nanomaterials. 498131

Ø   Tsai SW, Huang CC, Rau LR, Hsu FY. 2014. Fabrication of aligned carbon nanotube/ polycaprolactone/gelatin nanofibrous matrices for Schwann cell immobilization. Journal of Nanomaterials. 498131

Ø   Huang SB, Chang YH, Lee HC, Tsai SW, Wu MH. 2014. A pneumatically-driven microfluidic system for size-tunable generation of uniform cell-encapsulating collagen microbeads with the ultrastructure similar to native collagen. Biomedical Microdevices.1-10.

Ø   Tsai SW, Yu DS, Tsao SW, Hsu FY. 2013. Hyaluronan-cisplatin conjugate nanoparticles embedded in eudragit S100-coated pectin/alginate microbeads for colon drug delivery. International Journal of Nanomedicine.8:2399-407.

Ø   Tsai SW, Liou HM. 2013. Evaluation of pectin as a material for hepatocyte encapsulation. Micro and Nanosystems.5:113-7.

Ø   Tsai SW, Liaw JW, Kao YC, Huang MY, Lee CY, Rau LR, Huang CY, Wei KC, Yen TC. 2013. Internalized Gold Nanoparticles Do Not Affect the Osteogenesis and Apoptosis of MG63 Osteoblast-Like Cells: A Quantitative, In Vitro Study. PLoS ONE 8(10): e76545

Ø   Chien , H-W., Kuo , W-H., Wang, M-J., Tsai ,S-W., Tsai, W-B.(2012) ” Tunable Micropatterned Substrates Based on Poly(dopamine) Deposition via Microcontact Printing” Langmuir,28, 5775−5782 (SCI)

Ø   Tsai ,S-W., Liu. H-M., Lin, C-J., Kuo, K-L., Hung, Y-S., Weng, R-C., Hsu, F-Y. (2012) “MG63 Osteoblast-Like Cells Exhibit Different Behavior when Grown on Electrospun Collagen Matrix versus Electrospun Gelatin Matrix” PLoS ONE, 7, e31200 (SCI)

Ø   Pan, T-M., Chang, K-Y., Lin, C-W., Tsai, S-W., Wu, M-H. (2012) “Label-free detection of DNA using high-k Lu2Ti2O7 electrolyte-insulator-semiconductors” J. Mater. Chem., 22, 1358-1363 (SCI)

Ø   Pan, T-M., Chang, K-Y., Lin, C-W., Tsai, S-W., Wu, M-H. (2011) “Label-free detection of uric acid using a disposable poly-N-isopropylacrylamide as an encapsulating enzyme material based on high-k Tm2Ti2O7 electrolyte–insulator–semiconductor devices” Sensors and Actuators B 160, 850– 857 (SCI)

Ø   Wu, M-H., Wang, H-Y., Liu, H-L., Wang, S-S., Liu, Y-T., Chen, Y-M., Tsai, S-W., Lin, C-L. (2011). “Development of high throughput perfusion-based microbioreactor platform capable of providing tunable dynamic tensile loading to cells and its application for the study of bovine articular chondrocytes” Biomedical Microdevices, 13, 789-798 (SCI)

Ø   Wu, M. H., Lee, Y. F., Lin, C. W., Tsai, S. W., Wang, H. Y., and Pan, T. M. (2011) Development of high-k   Tm2Ti2O7 sensing membrane-based electrolyte-insulator-semiconductor for pH detection and its application for glucose biosensing using poly(N-isopropylacrylamide) as an enzyme encapsulation material, Journal of Materials Chemistry21, 539-547.

Ø   Liaw, J. W., Tsai, S. W., Chen, K. L., and Hsu, F. Y. (2010) Single-photon and two-photon cellular imagings of gold nanorods and dyes, Journal of Nanoscience and Nanotechnology10, 467-473.

Ø   Tsai, S. W., Cheng, Y. H., Chang, Y., Liu, H. L., and Tsai, W. B.(2010) Type I collagen structure modulates the behavior of osteoblast-like cells, Journal of the Taiwan Institute of Chemical Engineers41, 247-251.

Ø   Tsai, S. W., Chen, C. C., Liou, H. M., and Hsu, F. Y. (2010) Preparation and characterization of microspheres comprised of collagen, chondroitin sulfate, and apatite as carriers for the osteoblast-like cell MG63, Journal of Biomedical Materials Research - Part A93, 115-122.

Ø   Hsu, F. Y., Cheng, Y. Y., Tsai, S. W., and Tsai, W. B. (2010) Fabrication and evaluation of a biodegradable cohesive plug based on reconstituted collagen/γ-polyglutamic acid, Journal of Biomedical Materials Research - Part B Applied Biomaterials95, 29-35.

Ø   Tsai, S. W., Chen, C. C., Chen, P. L., and Hsu, F. Y. (2009) Influence of topography of nanofibrils of three-dimensional collagen gel beads on the phenotype, proliferation, and maturation of osteoblasts, Journal of Biomedical Materials Research - Part A91, 985-993.

會議論文

Ø   Lih-Rou Rau, Shu-Wei Tsao, Shiao-Wen Tsai . Hyaluronan-modified gold nanoparticles for laser-induced photothermal bubbles in carcinoma cells. 014 Tissue Engineering and Regenerative Medicine International Society-Asia Pacific Meeting (TERMIS-AP 2014), Daegu, Korea

Ø   Kao,Y-C., Huang, M-Y., Liaw, J-W., Tsai, S-W. (2012)“A quantitative in vitro approach to study cytotoxicity of gold nanoparticles as optical probes for cellular imaging” 9th World Biomaterials Congress, ChengDu, China

Ø   Kao,Y-C., Huang, M-Y., Liaw, J-W., Tsai, S-W. (2011) “Influence of gold nanoparticles on osteoblast-like cell growth and differentiation” 5th WACBE World Congress on Bioengineering, TAIWAN

Ø   Tsai,S-W., Liou,H-M., Hsu, F-Y. (2010) “Comparison of the Cellular Behaviors of MG63 Osteoblast-like Cells on the Collagen and Gelatin Electrospun Nanofibrous” International NanoBio Conference, Aug, Zurich

Ø   Tsai, S. W., Liou, H. M., and Hsu, F. Y. (2009) “Evaluation of pectin as material for hepatocyte encapsulation”17th InternationalSymposium on Microencapsulation, Sep, Japan (NSC 98-2221-E-019-004-)

Ø   Tsai, S. W., Hsu, F. Y., and Li, Z. R. (2009) “Preparation And Characterization Of High Water Content Hyaluronic Acid Hydrogel” International Conference on processing & manufacturing of advanced materials Processing, Fabrication, Properties,Applications, Aug, German

Ø   Lin, C.J., Tsai, S.W., Hsu, F.Y. (2009)  Influence of molecular-scale topography of  collagen and gelatin electrospun fibrous on the phenotype and proliferation of MG63 osteoblast-like cells,  ICMAT & IUMRS-ICA, June, Singapore (NSC -97-2221-E-182-045 )

Ø   劉恒良,劉彥廷,林峻立,蔡曉雯,吳旻憲(2009) 開發能提供機械張力刺激之高通量灌流式細胞培養系統:張力刺激行為電腦模擬分析 2009生化工程研討會

國際研討會論文

Ø   Hsu HT, Rau LR, Zeng YN, Kang YL, Tsai SW. “The impact of collagen nanofibril texture on cellular responses” Symposium on Biomedical Polymers and Interfaces. 2016, AU

Ø   Wang V, Rau LR, Liaw JW, Hsu FY, Tsai SW. “The photothermal effects of gold nanoparticles activated by low-level laser on mesenchymal stem cells” Australian Biomedical Engineering Conference. 2016, AU

Ø   Tsai SW, Rau LR, Chang YH, Hsu FY. Fabrication and characterization of mesoporous bioactive glass microsphere as drug delivery carriers. Fourth International Conference on Multifunctional, Hybrid and Nanomaterials. Spain, 09-13, March 2015

Ø   Tsai SW, Rau LR, Zeng YN, Kang YL. Construction of a cell containing, three-dimensional reconstituted aligned collagen fibril scaffold in a single step. 2015 Joint Congress of the IPITA-IXA-CTS. Australia, 15-19 November 2015

Ø   Tsai SW, Yu DS , Tsao SW and Hsu FY. Fabrication and characterization of Eudragit S100-coated pectin/alginate microcapsules containing cisplatin-hyaluronan nanoparticles for colon targeted delivery. 40th Annual Meeting & Exposition of the Controlled Release Society, July. 2013, Hawaii, America

Ø   Yang SI, Lei KF, Tsai SW, Hsu HT. Development of a Paper-based Carbon Nanotube Sensing Microfluidic Device for Biological Detection. 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. July. 2013, Osaka, Japan

專利與成果

Yang, J. D., Tsai, S. W., Chen, J. H., Yang, C. L., and Hsieh, Y. L. (2005) Method for producing water insolube polysaccaride, US aptent 6852255

Tsai, S. W., Yang, C. L., Chen, J. H., Chang, P. C., Su, L. T., and Jan, S. H. (2006) Method for preparing double-crosslinkined hyaluronic acid, R.O.C. patent I251596.