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長庚大學 生化與生醫工程研究所
分類清單
最後更新日期
2017-09-18

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蔡少偉

蔡少偉 Shau-Wei Tsai 教授

學 (經) 歷 :

成功大學化工博士

專        長:

酵素工程、生化工程、單元操作

研 究 成  果

期刊論文及專利等

分        機:

3415

實   驗   室:

生物反應器工程實驗室(工學大樓9樓)

email:

tsai@mail.cgu.edu.tw

學歷

成功大學     

化工博士

1982-1985

成功大學      

化工碩士

1977-1979

清華大學   

化工學士

1973-1977

經歷

長庚大學生化與生醫工程研究所

教授     

2005/08-迄今

長庚大學生化與生醫工程研究所  

所長

2006/08-2013/07

成功大學化學工程學系

教授

1989/08-2005/07

司圖加大學熱力與熱程工程研究所

訪問教授

2004/08-2004/10  

成功大學工學院

副院長

2002/09-2004/07  

成功大學化學工程學系  

系主任

1997/08-1999/07

成功大學教務處學服組

主任

1990/08-1993/07  

愛荷華大學化學及生化工程學系

訪問教授

1994/02-1995/01  

成功大學化學工程學系

副教授

1985/06-1989/07

麻省理工學院化學工程學系

訪問學者

1987/09-1988/06

成功大學化學工程學系

講師

1982/08-1985/05

   研究領域

酵素於有機合成應用

發酵與生化分離

化學反應工程

  期刊編審委員      

主編,化工,2000 ~ 2003

Journal of Molecular Catalysis B: Enzymatic, 2009 ~

Journal of the Taiwan Institute of Chemical Engineers (JTIChE), 2009 ~

科學發展,2000 ~ 迄今

作目錄

期刊論文

Ø   Tsai, S. W. 2017. “Quantitative insights into one-pot sequential asymmetric enzymatic catalytic processes”, JTIChE, 74, 79-88. 

Ø   Lee, I. C., Wu, Y. C., Tsai, S. W., Chen, C. H., Wu, M. H. 2017. “Fabrication of two-layer dissolving polyvinylpyrrolidone microneedles with different molecular weights for: In vivo insulin transdermal delivery. RSC Advances, 7, 5067-5075.

Ø   Lee, I. C., Lin, W. M., Shu, J. C., Tsai, S. W., Chen, C. H., Tsai, M. T. 2017. “Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice” J. Biomed. Mater. Research, Part A, 7, 5067-5075.

Ø   Lee, M. T., Lee, I. C., Tsai, S. W., Chen, C. H., Wu, M. H., Juang, Y. J. 2017. “Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch,” JTIChE, 70, 42-48.

Ø   Tsai, S. W., 2016. “Enantiopreference of Candida antarctica lipase B toward carboxylic acids: substrate models and enantioselectivity thereof,” J. Mol. Cat. B: Enzymatic, 127, 98-116.

Ø   H. T. Hsiao, Lin, S. Y. Tsai, S. W. 2016. “Quantitative insights and improvements of enzyme activity and stereoselectivity for CALB-catalyzed alcoholysis in two-step desymmetrization,” J. Mol. Cat. B: Enzymatic, 127, 82-88.

Ø   Kao, J. Y., Tsai, S. W. 2016. “Kinetic analysis for lipase-catalyzed regioselective methanolysis of (R)- and (S)-2-methylglutaric dipyrazolides for preparation of (R)-methyl 2-methyl-5-oxo-5-[1H-pyrazol-1-yl)pentanoate and (S)-methyl 4-methyl-5-oxo-5-[1H-pyrazol-1-yl)pentanoate,” JTIChE, 59, 120-125.

Ø   Chan, P. H., Tsai, S. W. 2016. “Two-step desymmetrization of dipyrazolidyl 3-phenylglutarate via lipase-catalyzed hydrolysis in organic solvents,” Chem. Eng. Sci., 139, 41-48.

Ø   Ko, P. T. Lee, I. C. Chen, M. C. Tsai, S. W. 2015. “Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds,” JTIChE, 51, 1-8.

Ø   Huang, Y. K. Tsai, S. W., 2014. “Kinetic and thermodynamic analysis of Candida antarctica lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents,” App. Microb. Biotechnol., 98, 621-628.

Ø   Wu, C. H., Wang, P. Y., Tsai, S. W., 2013. “Kinetic analysis for lipase-catalyzed hydrolysis of (R,S)-1,2,4-triazolides derived from N-Cbz-proline and (R,S)-N-Cbz-pipecolic acid,” JTIChE, 44, 146-151.

Ø   Wu, C. H., Pen, C. W., Wang, P. Y., Tsai, S. W., 2013. “An efficient lipase-catalyzed enantioselective hydrolysis of (R,S)-azolides derived from N-protected proline, pipecolic acid, and nipecotic acid,” App. Microb. Biotechnol. 97, 1581-1587.

Ø   Cheng, Y. L.,   Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic analysis for lipase-catalyzed hydrolytic resolution of (R,S)-alcohols though their azolyl carbamates,” Biopro. Biosys. Eng.35, 953-962.

Ø   Chen, J. R., Wu, C. H., Wang, P. Y., Tsai, S. W. 2012. “Kinetic and thermodynamic investigation of lipase-catalyzed hydrolysis of (R,S)-3-phenylbutyl azolides,“ IEC Research 51, 3580-3586.

Ø   Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2012. “(R,S)-2-Chlorophenoxyl pyrazolides as extreme substrates for improving lipase-catalyzed hydrolytic resolution,” Chirality 24, 60-66.

Ø   Wu, A. C., Wang, P. Y., Tsai, S. W., 2012. “Lipase-catalyzed regioselective hydrolysis of 3(5)-methylpyrazole-N-carboxylates in water-saturated organic solvents,” J. Mol. Cat. B: Enzymatic, 74, 41-47.

Ø   Cho, S. H., Wang, P. Y., Tsai, S. W., 2011. “Lipase-catalyzed hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates in biphasic media,” JTIChE 42, 408-412.

Ø   Ciou, J. F., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed alcoholytic resolution of (R,S)-flurbiprofenyl azolides for preparation of (R)-NO-flurbiprofen ester prodrugs,” Proc. Biochem. 46, 960-965.

Ø   Lin, Y. S., Wang, P. Y., Wu, A. C., Tsai, S. W., 2011. “Lipase-catalyzed enantioselective resolution of (R,S)-N-2-methylalkanoyl-3-(2-pyridyl)pyrazoles in organic solvents,” J. Mol. Cat. B: Enzymatic, 68, 245-249.

Ø   Wang, P. Y., Wu, C. H., Ciou, J. F., Wu, A. C., Tsai, S. W., 2010.“Kinetic resolution of (R,S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity,”J. Mol. Cat. B: Enzymatic, 66, 113-116.

Ø   Wu, A. C. Wang, P. Y. Lin, Y. S. Kao, M. F. Chen, J. R. Ciou, J. F. Tsai, S. W. 2010. “Improvements of enzyme activity and enantioselectivity in lipase-catalyzed alcoholysis of (R,S)-azolides,”J. Mol. Cat. B: Enzymatic, 62, 235-241.

Ø   Wang, P. Y. Chen, Y. J. Wu, A. C. Lin, Y. S. Kao, M. F. Chen, Ciou, J. F. Tsai, S. W. 2009. “(R,S)-Azolides as novel substrates for lipase-catalyzed hydrolytic resolution in organic solvents.”Adv. Syn. Cat., 351, 2333-2341.

Ø   Chen, H. M. Wang, P. Y., Tsai, S. W. 2009. “Carica papaya lipase-catalyzed transesterification resolution of secondary alcohols in organic solvents,”JTIChE, 40, 549-554.

Ø   Wang, P. Y., Tsai, S. W. 2009. “Modification of enzyme surface negative charges via covalent Immobilization for tailoring the activity and enantioselectivity,” JTIChE, 40, 364-370.

Ø   Wang, P. Y., Tsai, S. W. 2009. “Hydrolytic resolution of (R,S)-3-hydroxy-3-phenylpropionates by esterase from Klebsiella oxytoca: Effects of leaving alcohol, covalent immobilization and aqueous pH,”J. Mol. Cat. B: Enzymatic, 59, 70-75.

Ø   Wang, P. Y., Tsai, S. W. 2009. “Enzymatic hydrolytic resolution of (R,S)-tropic acid esters and (R,S)-ethyl α-methoxyphenylacetate in biphasic media,”J. Mol. Cat. B: Enzymatic, 57, 158-163.

會議論文

Ø   Hsiao, H. T., Lin, S. Y., Tsai, S. W. 2016, “Activity and stereoselectivity improvements for CALB-catalyzed alcoholysis in two-step desymmetrization,” The Fifth International Conference on Cofactors & Active Enzyme Molecule 2016, Toyama, Japan.

Ø   Hsiao, H. T., Wu, T. Y., Tsai, S. W., 2015. “Lipase-catalyzed desymmetrization of  3-methyl- and 3-phenyl-glutaric di-1,2,4-triazolides in organic solvents”, ACB 2015, KL, Malaysia.

Ø   Ko, P. T. Tzeng, Y. J. Tsai, S. W., 2015. “Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds”, Biomaterials International 2015, Kenting, ROC.

Ø   Huang Y. K., Tsai, S. W., “Candida antarctica Lipase B-catalyzed alcoholytic resolution of (R,S)-β-butyrolactone in organic solvents”, ACB-2013, New Delhi.

Ø   Tsai, S. W., 2012. “Combination of azolide chemistry and lipase specificity for preparing stereo- and regio-isomers,” APCChE 2012, Singapore.

Ø   Wu, A. C., Wang, P. Y., Tsai, S. W., 2011. “Lipase-catalyzed regioselective hydrolysis of 3(5)-methylpyrazole-N-carboxylates in water-saturated organic solvents,” Asia Congress on Biotechnology, Shanghai, China.

Ø   Kao, M. F., Lu, P. Y., Kao, J. Y., Wang, P. Y., Wu, A. C., Tsai, S. W., 2010. “(R,S)-2-chlorophenoxylpyrazolides as extreme substrates forimproving lipase-catalyzed hydrolytic resolution,” YABEC, Chung-Li, ROC.

Ø   Wang, P. Y., Tsai, S. W., 2010. “Kinetic resolution of (R,S)-pyrazolides containing substituents in the leaving pyrazole for increased lipase enantioselectivity,” AIChE Annual Meeting, Salt Lake City, USA.

Ø   Wu, A. C., Wang, P. Y., Tsai, S. W., 2010. ”Lipase-catalyzed hydrolytic resolution of pyrazole-N-carboxylate tautomers containing substituents,” APCChE-XIII, Taipei, ROC.

Ø   Wang, P. Y. Chen, Y. J. Wu, A. C. Lin, Y. S. Kao, M. F. Chen, Ciou, J. F. Tsai, S. W. 2009. “(R,S)-Azolides as novel substrates for lipase-catalyzed hydrolytic resolution in organic solvents,” APBio2009, Kobe, Japan.

Ø   Wang, P. Y., Tsai, S. W. 2009. “Modification of enzyme surface negative charges via covalent immobilization for tailoring the activity and enantioselectivity,” Biotrans2009, Berne, Switzerland.

其他著作

Ø  蔡少徫,2005,「二十一世紀新化學工程」,第八章:生化工程簡介,周更生主編,五南圖書出版社,141-151。

Ø  徐靄可、黃彥凱、蔡少偉,2013,明日世界之能源供給與化學品加值鏈,化工,60(2),83-89

專利與成果

Ø  蔡少偉、王培筠,2013,酵素動力分割方法,中華民國專利I388667號(有效期 2013/03/11-2029/08/20)。

Ø  Tsai, S. W. and Wang P. Y. 2013. “Method for producing an optically active compound”, US Patent 8377660.

Ø  Tsai, S. W. 2009, “Enzymatic resolution of an alpha-substituted carboxylic acid or an ester thereof by Carica papaya lipase”, Japan Patent 4247545

Ø  蔡少徫,2007,以木瓜脂肪分解酵素進行α-取代基酸或其酯類化合物之動力分割的方法,中華民國專利I276687號,(有效期 2007/03/21 -2024/06/29)

Ø  蔡少偉、張春生,2002,光學活性S形2-芳香取代基丙酸((S)-profens)或其S形酯類之製造方法,中華民國專利150558號。

Ø  Tsai, S. W. and Chang C. S. 2001. “Processes for preparing optically active (S)-a-aryl propionic acid or ester thereof”, US Patent 6201151.