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長庚大學 生化與生醫工程研究所
分類清單
最後更新日期
2017-06-21

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李亦淇

李亦淇 Lee, I-Chi 副教授

學( 經 )歷 :

台灣大學醫工博士

專        長:

高分子薄膜、生醫材料、組織工程、幹細胞研究

研 究 成  果:

期刊論文及專利等

分        機:

5985

實   驗   室:

幹細胞與生醫材料實驗室(工學大樓9樓)

e-mail

 iclee@mail.cgu.edu.tw

學歷

台灣大學                 

醫工博士      

2002/09-2007/01

台灣大學

醫工碩士

2000/09-2002/06

淡江大學

化工學士

1996/09-2000/06

經歷

長庚大學生化與生醫工程研究所

副教授

2015/08-

長庚大學生化與生醫工程研究所

助理教授

2010/08-2015/07

中央研究院基因體研究中心

院聘博士後研究員

2009/07-2010/07

中央研究院基因體研究中心

博士後研究員

2007/02-2009/06

研究領域

˙間葉幹細胞之分離、培養、與分化之研究

˙韌帶組織工程

˙高分子薄膜製備與相行為之研究

˙裂解性高分子薄膜製備與裂解機制之研究

˙細胞電泳技術於幹細胞鑑定之應用

˙小鼠胚胎肝臟幹細胞於生醫材料之研究

˙雙脂膜(lipid-bilayer)及聚電解質(polyelectrolyte)在生醫材料上之應用

˙微流體技術

獲獎紀錄

2009年生物科技研討會海報銀獎

著作目錄

期刊論文

Ø  Lee IC, Wu YC, Tsai SW, Chen CH, Wu MH.* (2017) "Fabrication of Two-layer Dissolving Polyvinylpyrrolidone Microneedles with Different Molecular Weights for in Vivo Insulin Transdermal Delivery," RSC Advances Accepted. (SCI, IF:3.289, Chemistry, multidiscipinary 49/193)

Ø  Lee IC*, Lin WM, Shu JC, Tsai SW, Chen CH, and Tsai MT. Formulation of two-layer dissolving polymeric microneedle patches for insulin transdermal delivery in diabetic mice. Journal of Biomedical Materials Research Part A. 2017, 105(1), 84-93 (SCI, IF: 3.263, Engineering Biomedical 13/76)

Ø  Lee MT, Lee IC, Tsai SW, Chen CH, Wu MH and Juang YJ*. Spin coating of polymer solution on polydimethylsiloxane mold for fabrication of microneedle patch. Journal of the Taiwan Institute of Chemical Engineers. 2017, 70, 42-48 (SCI, IF:3, Engineering, Chemical 19/134)

Ø  Lin YH*, Lee IC (equal first), Hsu WC, Hsu CH, Chang KP, Gao SS. Rapid fabrication method of a microneedle mold with controllable needle height and width. Biomedical microdevices. 2016. 18(5)85. (SCI, IF: 2.227 Engineering Biomedical 28/76)

Ø  Tsai MT, Lee IC*, Lee ZF, Liu HL, Wang CC, Choia YC, Chou HY, and Lee JD. In vivo investigation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence tomography. Biomedical optics express. 2016, 7(5), 1865-1876 (SCI, IF: 3.344, Optics 12/90)

Ø  Yi-Je Juang*, Yu Luen Deng, and I-Chi Lee. Membrane filtration: An unconventional route for fabrication of the flexible and dissolvable, polymer microneedle patches. Biomicrofluidics. 2016, 10, 044108. (SCI, IF: 2.708, Physics, fluids & plasmas 6/30)

Ø  Lee IC*, Chuang CC, and Wu YC. Niche Mimicking for Selection and Enrichment of Liver Cancer Stem Cells by Hyaluronic Acid-Based Multilayer Films. ACS applied materials and interfaces. 2015. DOI:10.1021/acsami.5b04436 (SCI, IF: 6.7 Materials science, multidiscipinary 26/251)

Ø  Ko PT, Lee IC, MC Chen, SW Tsai*. Polymer microneedles fabricated from PCL and PCL/PEG blends for transdermal delivery of hydrophilic compounds. Journal of the Taiwan Institute of Chemical Engineers. 2015, 51, 1-8. (SCI, IF:3, Engineering, Chemical 19/134)

Ø  Lee IC*, and Chang JF. Label-free Selection and Enrichment of Cancer Stem Cells by Layer by Layer Build-Up Polyelectrolyte Multilayer films. Colloids and Surfaces B: Biointerfaces 2015, 125, 120-126 (SCI, IF:4.152, Biophysics 14/74)

Ø  Lee IC*, Wu YC, Cheng EM, and Yang WT. Biomimetic niche for neural stem cell differentiation using PLL/HA multilayer films. Journal of biomaterials application 2015, 29(10), 1418-1427 (SCI, IF: 2.764, Engineering, Biomedical, Rank: 21/77)

Ø  Lee IC*, He JS, Lin KC, and Tsai MT*. Fabrication of a novel partial dissolving polymer microneedle patch for transdermal drug delivery. Journal of Materials Chemistry B. 2015, 3(2), 276-285 (SCI, IF: 4.726, Materials science, Biomaterials, 6/33)

Ø  Tao FF, Xiao X, Lei KF,* and Lee IC, Paper-based Cell Culture Microfluidic System. BioChip Journal. 2015, 9(2):97-104. (SCI, IF: 1.050, 70/78: Biochemical research methods)

Ø  Lei KF*, Lee IC* (eaqul contribution), Liu YC, and Wu YC. Successful Differentiation of Neural Stem/Progenitor Cells Cultured on Electrically Adjustable Indium Tin Oxide (ITO) Surface. Langmuir 2014 30, 14241-14249 (SCI, IF: 4.457, Materials science, multidiscipinary 31/251)

Ø  Lee IC*, and Wu YC. Facilitating the neural stem/ progenitor cell Niche for Neural Lineage Differentiation by polyelectrolyte multilayer films. Colloids and Surfaces B: Biointerfaces 2014, 121 54-65 (SCI, IF: 4.152, Biophysics 14/74)

Ø  Lee IC*, Lo TL, Young TH, Li YC, Chen, Nelson G, Chen CH and Chang YC*. Differentiation of Neural Stem/Progenitor Cells by Low Intensity Ultrasound. Ultrasound in Medicine and Biology. 2014, 40(9) 2195-2206 (SCI, IF: 2.214, Rank: 4/31)

Ø  Lee IC*, and Wu YC. Assembly of polyelectrolyte multilayer films on supported lipid bilayers to induce neural stem/progenitor cell differentiation into functional neurons. ACS applied materials and interfaces 2014, 6(16), 14439–14450 (SCI, IF: 6.7 Materials science, multidiscipinary 26/251)

Ø  Lee IC, Tsai HA, Liu YC, Shen CN and Chang YC*. Promoting Selection and Maintenance of Fetal Liver Stem/ Progenitor Cell Colonies by Supported Lipid Bilayer Based Materials. ACS applied and materials interfaces. 2014, 6(23), 20654-20663 (SCI, IF: 6.7Materials science, multidiscipinary 26/251)

Ø  Lee IC*. Effects of surface morphology variation on the cell behavior and degradation rate of Poly (L-Lactide) membranes. Micro and Nanosystems. 2013, 5, 118-125

Ø  Tsai HA, Wu RR, Lee IC, Chang HY, Shen CN* and Chang YC*. Selection, enrichment, and maintenance of self-renewal liver stem/progenitor cells utilizing polypeptide polyelectrolyte multilayer films. Biomacromolecules. 2010, 11, 994–1001 (SCI, IF: 5.75, Rank: 4/79)

Ø  Lee IC, Lee YT, Yu BY, Young TH. The behavior of mesenchymal stem cells on micropatterned PLLA membranes. J Biomed Mater Res. 2009;91A:929-938 (SCI, Impact Factor: 3.044, Rank: 12/70)

Ø  Shao HJ, Chen CS, Lee IC, Wang JH, Young TH Young. Designing a three-dimensional ePTFE-PLGA scaffold for tissue engineering. Artificial Organs. 2009, 33(4):309-317. (SCI, Impact Factor: 1.719, Rank: 33/70)

Ø  Chen YJ, Huang CH, Lee IC, Lee YT, Chen MH, Young TH. Effects of Cyclic Mechanical Stretching on the mRNA Expression of Tendon/Ligament-Related and Osteoblast-Specific Genes in Human Mesenchymal Stem Cells. Connective Tissue Research, 2008;49:1-8 (SCI, Impact Factor: 2.093, Rank: 18/61)

Ø  Lee IC, Wang JH, Lee YT, Young TH. Development of a useful technique to discriminate anterior cruciate ligament cells and mesenchymal stem cells-The application of cell electrophoresis. J Biomed Mater Res 2007;82A:230-237. (SCI, Impact Factor: 3.044, Rank: 12/70)

Ø  Lee IC, Wang JH, Lee YT, Young TH. The differentiation of mesenchymal stem cells by mechanical stress or/and co-culture system. Biochem Bioph Res Co 2007;352: 147-152. (SCI, Impact Factor: 2.749, Rank: 27/69)

Ø  DJ Lin, HH Chang, TC Chen, Lee YC, Cheng LP. Formation of porous poly (vinylidene fluoride) membranes with symmetric or asymmetric morphology by immersion precipitation in the water/TEP/PVDF system. European Polymer Journal 2006;42:1581–1594. (SCI, Impact Factor: 2.248, Rank: 12/74)

Ø  Lee IC, Cheng LP, Young TH. Role of phase diagram of membrane formation system in controlling the crystallinity and degradation rate of PLLA membranes. J Biomed Mater Res 2006;76A: 842-850. (SCI, Impact Factor: 3.044, Rank: 12/70)

Ø  Lee IC, Young TH. Preparation of PLLA membranes with different morphologies for culture of ligament cells. Biomedical Engineering-Applications, Basis, and Communications 2006;18: 185-189. (EI)

Ø  Liu HC, Lee IC, Wang JH, Yang SH, Young TH. Preparation of PLLA membranes with different morphologies for culture of MG-63 Cells. Biomaterials 2004;25:4047-4056. (SCI, Impact Factor: 7.883, Rank: 2/70)

研討會論文

國際學術研討會:

Ø   I-Chi Lee*, Yu-Chieh Wu. “Niche Mimicking for Induction of Neural Stem/Progenitor Cells by Multilayer Films Based System”, TERMIS-AP. Oral speaker. Invited speaker. (2016, Sep. 3-9)

Ø   I.C. Lee*, Y.C. Wu and C.C. Chuang. “Facilitating cancer stem cells microenvironment for label-free selection by using multilayer nanofilms”, BioNanoMed, Austria. (2016, April. 6-8)

Ø   Yung-Chiang Liu, I-Chi Lee*, Kin-Fong Lei. “Promotion and Guidance of Neural Network Formation on SU-8 Photoresist Microchannels Adjusted with Multilayer Films”, EMBC, Orlando, USA. (2016, August. 17-20)

Ø   Yung Chiang Liu, I-Chi Lee*, “Guidance and Measurement of Neural Network Formation on Indium Tin Oxide (ITO) based Multilayer Films”, SEMBA , Taiwan. (2016, Jan. 22-24).

Ø   Yu-Chieh Wu, I-Chi Lee*, “Label Free Selection of Pancreatic Cancer Stem Cells by Hyaluronic Acid Based Multilayer Films”, SEMBA , Taiwan. (2016, Jan. 22-24)

Ø   I-Chi Lee*, and Chun-Chieh Chuang. “Engineering Biointerfaces to Select and Enrich Cancer Stem Cell”, TERMIS world congress, Boston, U.S.A. (2015, Sep. 8-11)

Ø   Wei-Ming Ling and I-Chi Lee*, “Fabrication of Dissolving Polymeric Microneedle Pathes using Centrifugal Process and Application in the Transdermal Delivery of Insulin”, Biomaterials International 2015, Kenting, Taiwan. (2015, June 1-5)

Ø   Wen-Ting Yang and I-Chi Lee*,Induction of Neural Stem Cells by using Hydrogel Modified  with Polypeptide Films” Biomaterials International 2015, Kenting, Taiwan. (2015, June 1-5)

Ø   Yung Chiang Liu, I-Chi Lee*, “Label-Free Isolation of Glioblastoma Cancer Stem-Like Cells by Hydrogel Materials”, The 5th Asian Biomaterial Congress (ABMC5), Taipei, Taiwan. (2015, May6-9)

Ø   I-Chi Lee*, Yung-Chiang Liu, Yu-Chieh Wu, and Kin Fong Lei, “Induction of Neural Stem Cells on Indium Tin Oxide Surface”, Solid State Devices and Materials (SSDM 2014), Japan (2014, Sept. 8~11).

Ø   Wei-Ming Ling and I-Chi Lee*,Two-Layered Dissolving Microneedle Patches for Transdermal Delivery of Insulin”, 1st Global conference on Biomedical Engineering (GCBME), Taiwan (2014, Oct. 9-12). Poster Award.

Ø   Wen-Ting Yang and I-Chi Lee*,Functionalization of Hydrogel by using Polyelectrolyte Multilayer Films on the Induction of Neural Stem / Progenitor Cells”, 1st Global conference on Biomedical Engineering (GCBME), Taiwan (2014, Oct. 9-12).

Ø   Zen-Hao Chuang, Chun-Chieh Chuang and I-Chi Lee*, “Selection and Enrichment of Liver Cancer Stem Cells by Using Hyaluronan Based Polyelectrolyte Mutilayer Films”, 1st Global conference on Biomedical Engineering (GCBME), Taiwan (2014, Oct. 9-12).

Ø   I-Chi Lee* and Yu-Chieh Wu, “Biomimetic material triggered synaptic function on the induction of neural stem/ progenitor cells”, The 3rd International Symposium of Materials on Regenerative Medicine, Taiwan (2014, 08, 27-29). Excellent in Poster Award.

Ø   Yu-Chieh Wu, and I-Chi Lee*Enhancement of transdermal delivery efficiency by using dissolving polymeric microneedle patches”, The 3rd International Symposium of Materials on Regenerative Medicine, Taiwan (2014, 08, 27-29). Excellent in Poster Award.

Ø   I-Chi Lee* and Jen-fu Chang, “Selection and Enrichment of Cancer Stem Cells by Using Biomaterials”, SCM-6, Dresdon, Germany, (2013).

Ø   I-Chi Lee* and Li-Chieh Wu, “Effects of Polyelectrolyte Multilayer Films on Neural Stem/Progentior Cells” SCM-6, Dresdon, Germany, (2013).

Ø   I-Chi Lee*, “Selection and Maintenance of Stem Cell colonies on Biomaterials”, Invited speaker and Section Chair. Oral speaker. Invited speaker. RMSC 2011, China, (2011).

Ø   Yung-Chiang Liu, and I-Chi Lee*, “Selection and Maintenance of Liver Stem Cell colonies on Biomimetic Substrates, WACBE, (2011).

Ø   Tsu-Lin Lo, Yi-Chen Li, and I-Chi Lee*, “Effects of Low Intensity Ultrasound on Neural Stem Cells”, WACBE, (2011)

Ø   I-Chi Lee, Hsuan–Ang Tsai, Yin-Chih Chang, and Chia-Ning Shen “Cell interaction with polyelectrolyte multilayers conjugated on supported lipid bilayers”, 2009 ISBIE, Taiwan. (2009)

Ø   Hsuan–Ang Tsai, I-Chi Lee, Yin-Chih Chang, and Chia-Ning Shen “ Layer by layer polypeptide polyelectrolyte for efficient selection enrichment, and maintenance of stem cells in vitro”, 2009 ISBIE, Taiwan. (2009)

國內研討會論文:

Ø   Wen-Ting Yang and I-Chi Lee*, “Induction of Neural Stem Cells by using Hydrogel Modified with Polypeptide Films”, 第八屆桃園四校生命科技領域聯合學術研討會, Taiwan, (2015/5/22).

Ø   Wei-Ming Ling and I-Chi Lee*, Two-Layered Dissolving Microneedle Patches for Transdermal Delivery of Insulin, 第八屆桃園四校生命科技領域聯合學術研討會, Taiwan, (2015/5/22).

Ø   Jheng-Siou He, I-Chi Lee*, “The Application of Dissolving Polymeric Microneedle Patches on Sustained Transdermal Delivery”, 第七屆桃園四校生命科技領域聯合學術研討會, Taiwan, (2014). 特優

Ø   Che-Lun Hu, and I-Chi Lee*, “The Bio-effect of Neural Stem/Progenitor Cells on Novel Nerve conduits”, 第七屆桃園四校生命科技領域聯合學術研討會, Taiwan, (2014).

Ø   Chun-Chieh Chuang, and I-Chi Lee*, “Selection and Maintenance of Liver Cancer Stem Cells by Using Hyaluronan Based Polyelectrolyte Multilayer Films”, 第七屆桃園四校生命科技領域聯合學術研討會, Taiwan, (2014).

Ø   Jheng-Siou He, Kai-Che Lin, I-Chi Lee*, shang-yu Du, and Meng-Tsan Tsai. “The Study of Dissolving Polymeric Microneedle Patches on Transdermal Drug Delivery”, 醫工年會, Taiwan, (2013).

Ø   Che-Lun Hu, and I-Chi Lee* “The Bio-effect of Neural Stem/Progenitor Cells on Porous PVDF Nerve Membrane”, 醫工年會, Taiwan, (2013).

Ø   Chun-Chieh Chuang, and I-Chi Lee*,Lable-free Selection of Liver Cancer Stem Cells by Layer by Layer Build-Up Polyelectrolyte Multilayer Films”, 醫工年會, Taiwan, (2013).

Ø   Li-Chieh Wu, and I-Chi Lee* " The Bio-effect of Polyelectrolyte Multilayer Films on Neural Stem/Progenitor Cells ", 再生醫學會, Taiwan, (2013).

Ø   Jen-fu Chang, and I-Chi Lee*, “Selection and Enrichment of Liver Cancer Stem Cells by Using Polyelectrolyte Multilayer Films”, 再生醫學會, Taiwan, (2013).

Ø   Tsu-Lin Lo, Li YC and I-Chi Lee*, “Effects of Low Intensity Ultrasound on Neural Stem Cells”, 再生醫學會, Taiwan, (2012). 佳作

Ø   I-Chi Lee* and Tsu-Lin Lo, Determination of low intensity ultrasound stimulation on neural stem cells, SEMBA, Taiwan, (2012).

Ø   Li-Chieh Wu, and I-Chi Lee* "The Bio-effect of Polyelectrolyte Multilayers on Neural Stem Cells", 醫工年會, Taiwan, (2012). 優勝

Ø   Jen-fu Chang, and I-Chi Lee*, “Selection and Enrichment of Liver Cancer Stem Cells by Using Polyelectrolyte Multilayer Films”, 醫工年會, Taiwan, (2012). Oral. 優勝

Ø   Liu yung chiang, Ying-Chih Chang, Chia-Ning Shen, I-Chi Lee*, “Selection and Maintenance of Stem Cell colonies by Using Biomaterials”, 醫工年會, Taiwan, (2010)

Ø   I-Chi Lee, Hsuan–Ang Tsai, Yin-Chih Chang, and Chia-Ning Shen “Cell interaction with polyelectrolyte multilayers conjugated on supported lipid bilayers”, ISBIE, Taiwan. (2009)

Ø   Hsuan–Ang Tsai, I-Chi Lee, Yin-Chih Chang, and Chia-Ning Shen “ Layer by layer polypeptide polyelectrolyte for efficient selection enrichment, and maintenance of stem cells in vitro”, ISBIE, Taiwan. (2009)

Ø   I-Chi Lee, Hsuan–Ang Tsai, Yin-Chih Chang, and Chia-Ning Shen “Selection and Maintenance of Fetal Liver Stem/Progenitor Cell Colonies on Biomaterials”, 2009 Biotechnology Taiwan, Taiwan (2009).

Ø   I-Chi Lee, Hsuan–Ang Tsai, Chia-Ning Shen and Yin-Chih Chang “Expansion and differentiation of mouse fetal liver stem/progenitor cells in a three-dimensional culture system using poly vinyl alcohol”, 2008 Taiwan Society for Stem Cell Research (2008).

Ø   Hsuan–Ang Tsai, I-Chi Lee, Chia-Ning Shen and Yin-Chih Chang “Polyelectrolyte as Platform for Selective Adhesion of Self-Renewal Liver Stem/Progenitor Cells”, 2008 Taiwan Society for Stem Cell Research (2008).

Ø   I-Chi Lee, Hsuan–Ang Tsai, Chia-Ning Shen and Yin-Chih Chang “Expansion and differentiation of Mouse Fetal Liver Stem/Progenitor Cells in 3 Dimensional culture System on Poly Vinyl Alcohol Substrate”, 2008 ICBME, Singapore (2008). (Oral Presentation)

Ø   Hsuan–Ang Tsai, Chia-Ning Shen, I-Chi Lee, and Yin-Chih Chang “Using Polyelectrolyte multilayer films as platform for selective adhesion fo fetal liver stem/progenitor cells”, 2008 ICBME, Oral, Singapore (2008).

專書

Ø   Kin Fong Lei, I-Chi Lee and Yi-Chen Li. Advances in Drug Testing and Drug Delivery Systems. Nova Science Publishers.

Ø   Kin Fong Lei, I-Chi Lee, Tim C. Lei. Microfluidic Systems with Functional Patterned Surface for Biomedical Applications, Design of Polymeric Platforms for Selective Biorecognition. Chapter 11, P305-324.