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長庚大學 生化與生醫工程研究所
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最後更新日期
2017-09-18
賴瑞陽

 

賴瑞陽 Jui-Yang Lai 教授

學( 經 )歷:

國立清華大學博士

專        長:

生醫材料、表面工程、組織工程、細胞治療

研 究 成  果:

期刊論文及專利等

分        機:

3598

實   驗   室:

功能性生醫材料實驗室(工學大樓10樓)

e-mail

jylai@mail.cgu.edu.tw

 

  

學歷

國立清華大學             

化工博士

2001-2006

國立清華大學

化工碩士

1997-1999

國立中央大學

化工學士

1993-1997

 

 

經歷

長庚大學生化與生醫工程研究所

教授

2014/08-

長庚大學生化與生醫工程研究所        

副教授

2010/08-2014/07

長庚大學生化與生醫工程研究所

助理教授

2007/08-2010/07

長庚大學分子醫學研究中心

助理研究員

2007/05-2007/07

國立清華大學化學工程系

博士後研究員

2006/08-2007/05

 

  

研究領域

˙生醫材料

˙組織工程/再生醫學

˙藥物/基因控制釋放

˙細胞/組織與材料交互作用

˙眼科學

 

 

學術編審

˙Associate Editor, Advances in Materials Physics and Chemistry

˙Editorial Board Member, Asian Journal of Biological and Life Sciences

˙Editorial Board Member, Asian Journal of Pharmaceutical and Biological

    Research

˙Editorial Board Member, International Journal of Pharmacy and Medical Sciences

˙Editorial Board Member, Journal of Chemical Engineering and Materials Science

˙Editorial Board Member, Journal of Developmental Biology and Tissue

    Engineering

˙Editorial Board Member, Journal of Transplantation Technologies & Research

˙Editorial Board Member, TheScientificWorldJOURNAL

˙Journal Reviewer, ACS Applied Materials & Interfaces

˙Journal Reviewer, Acta Biomaterialia

˙Journal Reviewer, Advanced Functional Materials

˙Journal Reviewer, Advances in Materials Physics and Chemistry

˙Journal Reviewer, African Journal of Biochemistry Research

˙Journal Reviewer, African Journal of Biotechnology

˙Journal Reviewer, Analytical Chemistry

˙Journal Reviewer, Asian Journal of Pharmaceutical and Biological Research

˙Journal Reviewer, Biomacromolecules

˙Journal Reviewer, Clinical Ophthalmology

˙Journal Reviewer, Cornea

˙Journal Reviewer, International Journal of Nanomedicine

˙Journal Reviewer, International Journal of Pharmaceutics

˙Journal Reviewer, Investigative Ophthalmology & Visual Science

˙Journal Reviewer, Journal of Biomedical Materials Research Part B-Applied

    Biomaterials

˙Journal Reviewer, Journal of Chemical Engineering and Materials Science

˙Journal Reviewer, Journal of Developmental Biology and Tissue Engineering

˙Journal Reviewer, Journal of Medical and Biological Engineering

˙Journal Reviewer, Journal of Polymer Engineering

˙Journal Reviewer, Macromolecular Bioscience

˙Journal Reviewer, Materials Science & Engineering C-Materials for Biological

    Applications

˙Journal Reviewer, PLoS One

˙Journal Reviewer, Recent Patents on Anti-Cancer Drug Discovery

˙Journal Reviewer, Recent Patents on Biomedical Engineering

˙Journal Reviewer, Tissue Engineering

˙Journal Reviewer, Tissue Engineering Part A

˙Journal Reviewer, Tissue Engineering Part B

˙Conference Reviewer, Annual Symposium of the Biomedical Engineering Society

    of ROC

˙Conference Reviewer, Annual Meeting of the Polymer Society, Taipei

˙Grant Reviewer, Chang Gung Memorial Hospital

˙Grant Reviewer, National Science Council of Republic of China

˙Grant Reviewer, Veterans General Hospitals University System of Taiwan Joint

    Research Program

 

 

獲獎紀錄

˙Who's Who in the World 2013 (30th Edition); Marquis Who's Who, NJ, USA

˙International Health Professional of the Year 2012; The International

   Biographical Centre of Cambridge, England

˙Third Place Oral Presentation Award [Yu TC]; 2012 Annual Meeting of

   Formosa Association of Regenerative Medicine

˙Third Place Oral Presentation Award [Li YT]; 2012 Annual Meeting of

   Formosa Association of Regenerative Medicine

˙Outstanding English Oral Presentation Gold Award; 35th Annual Meeting of

   the Polymer Society, Taipei (2012)

˙Who's Who in Medicine and Healthcare 2011-2012 (8th Edition); Marquis

   Who's Who, NJ, USA

˙Oral Presentation Award; 2011 Annual Meeting and Symposium of

   Biomaterials & Controlled Release Society, Taiwan (BCRST) 

˙Poster Paper Award; 34th ROC Polymer Symposium

˙Best Poster Presentation Award; 2008 Annual Conference of Tissue

   Engineering and Regenerative Medicine International Society-Asian Pacific

   Region (2008 TERMIS-AP)

˙Best Poster Paper Award; 2005 Symposium on Biomaterials and Drug

   Delivery Systems

˙Best Project Presentation Award; Veterans General Hospitals University

   System of Taiwan Joint Research Program

˙Poster Paper Award; 2004 Annual Symposium of the Biomedical Engineering

   Society of ROC

˙Best Poster Paper Award; 2004 Taiwan-Japan Advanced Biomaterials

   Symposium

˙Poster Paper Award; The 45th Anniversary Congress of Taiwan

   Ophthalmological Society and 7th Taipei International Symposium on

   Ophthalmology

˙Best Oral Paper Award; 2003 Symposium on Biomaterials and Drug Delivery

   Systems

˙Triangle Research Collaboration Award; 3rd Asian International Symposium

   on Biomaterials and Drug Delivery Systems

 

 

著作目錄

期刊論文

Ø  Lai, J.-Y. (2016) “Hyaluronic acid concentration-mediated changes in structure and function of porous carriers for corneal endothelial cell sheet delivery”, Mater. Sci. Eng. C-Mater. Biol. Appl., 59, 411-419.

Ø  Chou, S.-F., Lai, J.-Y., Cho, C.-H., Lee, C.-H. (2016) “Relationships between surface roughness/stiffness of chitosan coatings and fabrication of corneal keratocyte spheroids: Effect of degree of deacetylation”, Colloid Surf. B-Biointerfaces, 142, 105-113.

Ø  Sun, C.-C., Chou, S.-F., Lai, J.-Y., Cho, C.-H., Lee, C.-H. (2016) “Dependence of corneal keratocyte adhesion, spreading, and integrin β1 expression on deacetylated chitosan coating”, Mater. Sci. Eng. C-Mater. Biol. Appl., 63, 222-230.

Ø  Chou, S.-F., Luo, L.-J., Lai, J.-Y., Ma, D.H.-K. (2016) “On the importance of Bloom number of gelatin to the development of biodegradable in situ gelling copolymers for intracameral drug delivery”, Int J Pharm., 511(1), 30-43.

Ø  Lai, J.-Y., Luo, L.-J. (2015) “Antioxidant gallic acid-functionalized biodegradable in situ gelling copolymers for cytoprotective antiglaucoma drug delivery systems”, Biomacromolecules, 16(9), 2950-2963.

Ø  Lai, J.-Y., Cheng, H.-Y., Ma, D.H.-K. (2015) “Investigation of overrun-processed porous hyaluronic acid carriers in corneal endothelial tissue engineering”, PLoS One, 10(8), e0136067.

Ø  Lai, J.-Y. (2015) “Carbodiimide cross-linking of amniotic membranes in the presence of amino acid bridges”, Mater. Sci. Eng. C-Mater. Biol. Appl., 51, 28-36.

Ø  Lai, J.-Y., Luo, L.-J. (2015) “Effect of riboflavin concentration on the development of photo-cross-linked amniotic membranes for cultivation of limbal epithelial cells”, RSC Adv., 5(5), 3425-3434.

Ø  Lai, J.-Y.* (2014) “Effect of chemical composition on corneal tissue response to photopolymerized materials comprising 2- hydroxyethyl methacrylate and acrylic acid, Mater. Sci. Eng. C-Mater. Biol. Appl., 34, 334-340.

Ø  Lai, J.-Y.* (2014) “Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid”, Carbohydr. Polym., 101, 203-212.

Ø  Lai, J.-Y.* (2014) “Interrelationship between cross-linking structure, molecular stability, and cytocompatibility of amniotic membranes cross-linked with glutaraldehyde of varying concentrations”, RSC Adv., 4(36), 18871-18880.

Ø  Lai, J.-Y.* (2014) “Biofunctionalization of gelatin microcarrier with oxidized hyaluronic acid for corneal keratocyte cultivation", Colloid Surf. B-Biointerfaces, 122, 277-286.

Ø  Lai, J.-Y.*, Wang, P.-R., Luo, L.-J., Chen, S.-T. (2014) “Stabilization of collagen nanofibers with L-lysine improves the ability of carbodiimide cross-linked amniotic membranes to preserve limbal epithelial progenitor cells”, Int. J. Nanomed., 9, 5117-5130.

Ø  Lai, J.-Y.* (2014) “Interrelationship between cross-linking structure, molecular stability, and cytocompatibility of amniotic membranes cross-linked with glutaraldehyde of varying concentrations”, RSC Adv., 4(36), 18871-18880.

Ø  Lai, J.-Y.* (2014)“Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid”, Carbohydr. Polym., 101, 203-212.

Ø  Lai, J.-Y.*, “Effect of chemical composition on corneal tissue response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid”, Mater. Sci. Eng. C-Mater. Biol. Appl., 34, 334-340.

Ø  Lai, J.-Y.*,  Lue, S.-J., Cheng, H.-Y., Ma, D.H.-K. (2013) “Effect of matrix nanostructure on the functionality of carbodiimide cross-linked amniotic membranes as limbal epithelial cell scaffolds”, J. Biomed. Nanotechnol., 9(12), 2048-2062.

Ø  Lai, J.-Y.* , Ma, D.H.-K. (2013) “Glutaraldehyde cross-linking of amniotic membranes affects their nanofibrous structures and limbal epithelial cell culture characteristics”, Int. J. Nanomed., 8, 4157-4168

Ø  Lai, J.-Y.* (2013) “Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio”, Drug Des. Dev. Ther., 7, 1273-1285.

Ø  Lai, J.-Y.* (2013) “Effect of chemical composition on corneal cellular response to photopolymerized materials comprising 2-hydroxyethyl methacrylate and acrylic acid”, Mater. Sci. Eng. C-Mater. Biol. Appl., 33(7), 3704-3710.

Ø  Lai, J.-Y.* (2013) “Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery”, J. Mater. Sci.-Mater. Med., 24(9), 2201-2210.

Ø  Lue, S.-J., Chen, B.-W., Shih, C.-M., Chou, F.-Y., Lai, J.-Y., Chiu, W.-Y. (2013)“Micron- and nano-sized poly(N-isopropylacrylamide-co-acrylic acid) latex syntheses and their applications for controlled drug release”, J. Nanosci. Nanotechnol., 13(8), 5305-5315.

Ø  Chou, F.-Y., Lai, J.-Y. (Equal First Author), Shih, C.-M., Tsai, M.-C., Lue, S.-J. (2013) “In vitro biocompatibility of magnetic thermo-responsive nanohydrogel particles of poly(N-isopropylacrylamide-co-acrylic acid) with Fe3O4 cores: Effect of particle size and chemical composition”, Colloid Surf. B-Biointerfaces, 104, 66-74.

Ø  Chou, F.-Y., Shih, C.-M., Lai, J.-Y., Chiu, W.-Y., Lue, S.-J. (2013) Time-resolved polymer propagation for acrylic acid-mediated nanolatexes containing magnetic Fe3O4 cores”, J. Nanosci. Nanotechnol., 13(3), 2147-2152.

Ø  Lai, J.-Y.*, Ma, D.H.-K., Lai, M.-H., Li, Y.-T., Chang, R.-J., Chen, L.-M. (2013) “Characterization of cross-linked porous gelatin carriers and their interaction with corneal endothelium: biopolymer concentration effect”, PLoS One, 8(1), e54058.

Ø  Lai, J.-Y.* (2013) “Corneal stromal cell growth on gelatin/chondroitin sulfate scaffolds modified at different NHS/EDC molar ratios”, Int. J. Mol. Sci., 14(1), 2036-2055.

Ø  Lai, J.-Y.*, Hsieh, A.-C. (2011) "A gelatin-g-poly(N-isopropylacrylamide) biodegradable in situ gelling delivery system for the intracameral administration of pilocarpine",Biomaterials. (SCI 7.883; 2/70 in ENGINEERING, BIOMEDICAL) [Selected as Journal Leading Opinion Paper] [Featured as Key Scientific Journal Article in LeadDiscovery] [Featured as Key Scientific Article in Global Medical Discovery]

Ø  Lai, J.-Y.*, Tu, I.-H. (2011) "Adhesion, phenotypic expression, and biosynthetic capacity of corneal keratocytes on surfaces coated with hyaluronic acid of different molecular weights", Acta Biomater. (SCI 4.824; 3/70 in ENGINEERING, BIOMEDICAL) [Featured as Key Scientific Article in Global Medical Discovery]

Ø  Lai, J.-Y.*, Wang, T.-P., Li, Y.-T., Tu, I.-H. (2011) "Synthesis, characterization and ocular biocompatibility of potential keratoprosthetic hydrogels based on photopolymerized poly(2-hydroxyethyl methacrylate)-co-poly(acrylic acid)", J. Mater. Chem. (SCI 5.101; 16/225 in MATERIALS SCIENCE, MULTIDISCIPLINARY)

Ø  Ma, D.H.-K., Lai, J.-Y., Yu, S.-T., Liu, J.-Y., Yang, U., Chen, H.-C., Yeh, L.-K., Ho, Y.-J., Chang, G., Wang, S.-F., Chen, J.-K., Lin, K.-K. (2011) "Up-regulation of heat shock protein 70-1 (Hsp70-1) in human limbo-corneal epithelial cells cultivated on amniotic membrane: a proteomic study", J. Cell. Physiol. (SCI 3.986; 13/78 in PHYSIOLOGY)

Ø  Lai, J.-Y.* , Li, Y.-T. (2011) "Influence of cross-linker concentration on the functionality of carbodiimide cross-linked gelatin membranes for retinal sheet carriers", J. Biomater.Sci.-Polym. Ed., 22(1-3), 277-295. (SCI 1.842; 25/79 in POLYMER SCIENCE)

Ø  Lai, J.-Y.* , Li, Y.-T., Wang, T.-P. (2010) "In vitro response of retinal pigment epithelial cells exposed to chitosan materials prepared with different cross-linkers", Int. J. Mol. Sci.,11(12), 5256-5272. (SCI 2.279; 41/147 in CHEMISTRY, MULTIDISCIPLINARY)

Ø  Ma, D.H.-K., Lai, J.-Y.*, Cheng, H.-Y., Tsai, C.-C., Yeh, L.-K. (2010) "Carbodiimide cross-linked amniotic membranes for cultivation of limbal epithelial cells", Biomaterials, 31(25), 6647-6658. (SCI 7.883; 2/70 in ENGINEERING, BIOMEDICAL)

Ø  Lai, J.-Y.* (2010) "Biocompatibility of chemically cross-linked gelatin hydrogels for ophthalmic use", J. Mater. Sci.-Mater. Med., 21(6), 1899-1911. (SCI 2.325; 20/70 in ENGINEERING, BIOMEDICAL)

Ø  Lai, J.-Y.* , Li, Y.-T. (2010) "Evaluation of cross-linked gelatin membranes as delivery carriers for retinal sheets", Mater. Sci. Eng. C-Mater. Biol. Appl., 30(5), 677-685. (SCI 2.180; 15/25 in MATERIALS SCIENCE, BIOMATERIALS)

Ø  Lai, J.-Y.* , Li, Y.-T. (2010) "Functional assessment of cross-linked porous gelatin hydrogels for bioengineered cell sheet carriers", Biomacromolecules, 11(5), 1387-1397.(SCI 5.327; 4/79 in POLYMER SCIENCE)

Ø  Lai, J.-Y.* , Ma, D.H.-K., Cheng, H.-Y., Sun, C.-C., Huang, S.-J., Li, Y.-T., Hsiue, G.-H. (2010) "Ocular biocompatibility of carbodiimide cross-linked hyaluronic acid hydrogels for cell sheet delivery carriers", J. Biomater. Sci.-Polym. Ed., 21(3), 359-376. (SCI1.842; 25/79 in POLYMER SCIENCE)

Ø  Chen, H.-C., Chen, H.-L., Lai, J.-Y., Chen, C.-C., Tsai, Y.-J., Kuo, M.-T., Chu, P.-H., Sun, C.-C., Chen, J.-K., Ma, D.H.-K. (2009) "Persistence of transplanted oral mucosal epithelial cells in human cornea", Invest. Ophthalmol. Vis. Sci., 50(10), 4660-4668. (SCI 3.466; 5/56 in OPHTHALMOLOGY)

Ø  Lai, J.-Y.* (2009) "The role of Bloom index of gelatin on the interaction with retinal pigment epithelial cells", Int. J. Mol. Sci., 10(8), 3442-3456. (SCI 2.279; 41/147 in CHEMISTRY, MULTIDISCIPLINARY) [Invited Paper]

Ø  Ma, D.H.-K., Chen, H.-C., Lai, J.-Y., Sun, C.-C., Wang, S.-F., Lin, K.-K., Chen, J.-K. (2009) "Matrix revolution: molecular mechanism for inflammatory corneal neovascularization and restoration of corneal avascularity by epithelial stem cell transplantation", Ocul. Surf., 7(3), 128-144. (SCI 3.103; 7/56 in OPHTHALMOLOGY)

Ø  Lai, J.-Y.* , Lin, P.-K., Hsiue, G.-H., Cheng, H.-Y., Huang, S.-J., Li, Y.-T. (2009) "Low Bloom strength gelatin as a carrier for potential use in retinal sheet encapsulation and transplantation", Biomacromolecules, 10(2), 310-319. (SCI 5.327; 4/79 in POLYMER SCIENCE)

專書論文

Ø  Lai, J.-Y.* (2011) "Biocompatibility assessment of gelatin carriers used in corneal endothelial cell delivery", In: Advances in Condensed Matter and Materials Research. Volume 8 (Geelvinck, H., Reynst, S., Eds.), Nova Science Publishers, New York, pp. 75-96, ISBN: 978-1608761593. [Invited Book Chapter]

Ø  Lai, J.-Y.* (2011) "Porous gelatin hydrogel carriers: evaluation of cross-linking degree for optimal cell delivery performance", In: Proceedings of the First International Symposium on Bioengineering (Chua, C.K., Lee, M.Y., Guan, Y.L., Chen, J.P., Luo, K.Q., Lai, C.S., Kwoh, C.K., Lee, J.D., Chian, K.S., Wu, S.L., Eds.), Research Publishing, Singapore, pp. 273-281, ISBN: 978-9810876159. [Invited Book Chapter]

Ø  Lai, J.-Y., Hsiue, G.-H. (2010) "Corneal endothelial reconstruction with a bioengineered cell sheet", In: Corneal Endothelial Transplant DSAEK, DMEK & DLEK (John, T., Ed.), Jaypee Brothers Medical Publishers, New Delhi, pp. 405-420, ISBN: 978-8184487923.

研討會論文

Ø  Lai, J.-Y.* (2014) “Divinyl sulfone cross-linked amniotic membranes for limbal epithelial cell cultivation”, 86th Annual Meeting of the Association for Research in Vision and Ophthalmology, May 4-8, Orlando, Florida, USA. Abstract: Invest. Ophthalmol. Vis. Sci., 55, E-Abstract 5175.

Ø  Lai, J.-Y.* (2011) "Thermo-responsive and biodegradable hydrogels as injectable carriers for pilocarpine delivery in glaucoma treatment", BIT Life Sciences' 1st Annual Symposium of Drug Delivery Systems, Nov. 3-5, Shenzhen, China. [Invited Speaker & Session Co-Chair]

Ø  Lai, J.-Y., (2011) "Porous gelatin hydrogel carriers: evaluation of cross-linking degree for optimal cell delivery performance", The First International Symposium on Bioengineering, Jan. 19, Singapore. [Invited Speaker]

Ø  Lai, J.-Y.* (2010) "Development of biomaterial carriers for ocular tissue engineering and regenerative medicine", BIT Life Sciences' 3rd Annual World Congress of Regenerative Medicine & Stem Cells 2010, Dec. 5-7, Shanghai, China. [Invited Speaker]

Ø  Lai, J.-Y.* (2010) "Development of porous gelatin hydrogels for corneal cell sheet delivery", 13th Asia Pacific Confederation of Chemical Engineering Congress, Oct. 5-8, Taipei, Taiwan, ROC. [Selected Speaker]

Ø  Lai, J.-Y.*, Hsiue, G.-H. (2009) "Functional biomaterials for corneal endothelial cell therapy and regenerative medicine", Biomaterials Asia 2009, Apr. 5-8, Hong Kong.[Invited Speaker]

 

專利與成果

Ø  Lai, J.-Y. , Hsieh, A.-C., Lu, P.-L. "Hydrogel-forming polymer, and preparation process and uses thereof", US Patent Application #13/354467 (Jan. 20, 2012).

Ø  Lai, J.-Y.* , Hsieh, A.-C., Lu, P.-L. "Hydrogel-forming polymer, and preparation process and uses thereof", ROC Patent Application #100120532 (Jun. 13, 2011).

Ø  Hsiue, G.-H., Lai, J.-Y. "Biopolymer-bioengineered cell sheet construct", US Patent Application #12/494465 (Jun. 30, 2009).

Ø  Hsiue, G.-H., Lai, J.-Y. "Biopolymer-bioengineered cell sheet construct", US Patent Application #11/508241 (Aug. 23, 2006).

Ø  Hsiue, G.-H., Lai, J.-Y. "Biopolymer-bioengineered cell sheet construct for tissue reconstruction and method for making an implant for reconstructing corneal endothelium in a patient", ROC Patent #I314449 (Sep. 11, 2009).