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長庚大學 生化與生醫工程研究所
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最後更新日期
2017-06-21
劉繼賢

 

 

 

 

劉繼賢Chi-Hsien Liu  教授

學( 經 )歷 :

國立清華大學博士

專        長:

幹細胞技術、生化工程、組織工程、奈米生醫技術

研 究 成  果:

期刊論文及專利等

分        機:

3146

實   驗   室:

細胞工程實驗室(工學大樓9樓)

e-mail:

chl@mail.cgu.edu.tw

 

 

學歷

清華大學               

化學工程研究所博士

1998-2001

大同工學院

化學工程研究所碩士

1990-1992

大同工學院

生物工程系學士

1986-1990

 

 

經歷

長庚大學生化生醫工程所

教授兼所長

2013-迄今

長庚大學生化生醫工程所

副教授

2007-2013

長庚大學生化生醫工程所

助理教授

2003-2007

食品工業發展研究所

研究員

2002-2003

懷德生技化學公司

生技處經理

2001-2002

美商安力達生技公司

專案經理

1998-2001

食品研究所

副研究員

1992-1998

 

 

 

研究領域

奈米技術之相關研究

生醫奈米微粒之製備與應用

載藥奈米微粒之藥物控制釋放

載藥奈米微粒之眼睛、皮膚傳遞

磁性奈米微粒之生化分離與基因傳遞

 

 

專業證照

環境工程技師

消防設備師

 

 

著作目錄

期刊論文

Ø     Liu, C. H.*, Lai, H.Y., Wu, W.C., 2017, Facile Synthesis of magnetic iron oxide nanoparticles for nattokinase isolation, Food and Bioproducts Processing, Accepted.

Ø     Liu, C. H.*, Tsao, M.H., Sahoo, S. L, Wu, W. C. 2016, Magnetic nanoparticles with fluorescence and affinity for DNA sensing and nucleus staining, RSC Advances, DOI:10.1039/c6ra25610d, Accepted.

Ø     Liu, C. H.*, Lee, W.S., Wu, W. C. 2016, Photodynamic inactivation against Pseudomonas aeruginosa by curcumin microemulsions, RSC Advances, 6, 63013-63022.

Ø     Rout, B., Liu, C. H.*, Wu, W. C. 2016, Enhancement of photodynamic inactivation against Pseudomonas aeruginosa by a nano-carrier approach. Colloids and Surfaces B: Biointerfaces, 140:472-480.

Ø     Liu, C. H., Huang, Y. C., Jhang, J. W., Liu, Y. H., Wu, W. C., 2015 Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion, RSC Advances, 5, 100923 – 100933.

Ø     Sahoo, S. L, Liu, C. H., 2015, Adsorption behaviors of DNA by modified magnetic nanoparticles: Effect of spacer and salt, Colloids and Surfaces A: Physicochem. Eng. Aspects, 482, 184–194.

Ø     Liu, C. H., Lai, K.Y., Wu, W.C., Chen,Y.J., Lee, W.S., Hsu, C.Y., 2015, In Vitro Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions, Chemical Pharmaceutical Bulletin, 63(2), 59-67

Ø   Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø   Wu, W C, Liu, C. H, Chen C. C., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2014, Lens subluxation after plasmin and SF6 injections in rabbit eyes, PLOS ONE,9 (11) e1129573.

Ø   Liu, C. H., Chiu, H.C., Wu, W.C., Sahoo, S.L., Hsu, C.Y., 2014,Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Volume 2014, Article ID 304694.

Ø   Liu, C. H., Sahoo, S.L. Tsao, M.H., 2014, Acridine orange coated magnetic nanoparticles for nucleus labeling and DNA adsorption, Colloids and Surfaces B: Biointerfaces, 115, 150-156

Ø   Chi Hsien Liu, Hao-Che Chiu, Wei-Chi Wu and Ching-Yun Hsu, Novel Lutein Loaded Lipid Nanoparticles on Porcine Corneal Distribution, Journal of Ophthalmology, Accepted

Ø   Hou, H.Y. Fu, S.H., Liu, C. H., Chen, J.P., Hsu, B.R.S., 2013, The graft survival protection of subcutaneous allogeneic islets with hydrogel grafting and encapsulated by CTLA4Ig and IL1ra, Polymer Journal, 46(2), 136-144.

Ø   Lin, L. T., Wang, B. S., Chen, J. C., Liu, C. H., Chou, Chiu, C., S. J., Chang, W. Y., Liu,R. S., Chang, C. A., Lee, Y. J., 2013, mPlum-IFP 1.4 fluorescent fusion protein may display Förster resonance energy transfer associated properties that can be used for near-infrared based reporter gene imaging. J. Biomed. Opt. 18(12), 126013

Ø   Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425,

Ø   Liu, C. H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930

Ø   Liu, C. H., Hsien Y. F. 2013, Adsorption behaviors of nucleic acid by cationic magnetic nanoparticles, Applied Mechanics Materials, Vol. (284-287) 271-275 (EI, 其他)

Ø   Liu,C.H., Cheng M. S. 2013, Nanoparticles composed by oligochitosan and polyethylenimine for gene delivery, Applied Mechanics Materials, Vol. (284-287) 412-418 (EI, 其他)

Ø   Liu, C. H., Huang H. Y. 2013, In vitro anti-Propionibacterium activity by curcumin containing vesicle system. Chemical Pharmaceutical Bulletin, 61(4): 419-425 (SCI)

Ø   Liu, C. H., Wu, W.C., Lai, H. Y., 2013, Adsorption of nattokinase by amino acid-conjugated magnetic nanoadsorbents, Separation Science Technology, 48(6) 923-930 (SCI)

Ø   Liu, C. H., Huang H. Y., 2012, Antimicrobial activity of curcumin-loaded myristic acid microemulsions against Staphylococcus epidermidis, Chemical Pharmaceutical Bulletin (1.657, 170/261) 60(9):1118-24

Ø   Wu, W C, Liu, C. H., Chen C. C., et al., 2012, Efficient vitreolysis by combining plasmin and sulfur hexafluoride injection in a preclinical study in rabbit eyes, Molecular Vision, 18:2361-2370

Ø   Liu, C. H., Wu, W.C.,Lai, H. Y., Hou, H. Y., 2011, Magnetic purification of plasminogen from human plasma by specific lysine affinity, J. Bioscience and Bioengineering 112(3):219-24.,

Ø   Liu, C. H., Chang, F.Y., 2011, Development and characterization of eucalyptol microemulsions for topic delivery of curcumin, Chem Pharm Bull., 59(2):172-8.

Ø   Wu, W.C., Chen, C.C., Liu, C. H., Wang, N.K., Chen, K.J., Chen T.L., Hwang, Y.S., Li, L.M., Lai, C.C., 2011, Plasmin treatment accelerates vascular endothelial growth factor clearance from rabbit eyes. Invest Ophthalmol Vis Sci.52(9),6162-7.

Ø   Liu, C. H., Chang, F. Y., Hung, D.-K., 2011, Terpene microemulsions for transdermal curcumin delivery: Effects of terpenes and cosurfactants, Colloids and Surfaces B: Biointerfaces, 82, 63–70

Ø   Peng, L.C., Liu, C. H., Kwan, C.C., Huang, K.F., 2010, Optimization of water-in-oil nanoemulsions by mixed surfactants Colloids and Surfaces A: Physicochemical and Engineering Aspects, 370, 136–142

Ø   Liu, C. H., Yu, S. Y., 2010, Cationic nanoemulsions as non-viral vectors for plasmid DNA delivery, Colloids and Surfaces B: Biointerfaces, 79(2) 509-515.

Ø   Liu, C. H., Wu, C. T., 2010, Optimization of nanostructured lipid carriers for lutein delivery, Colloids and Surfaces A: Physicochem. Eng. Spects, 353(2-3) 149-156.

Ø   Liu, C. H., Wu, C. T., Fang, J. Y., 2010, Characterization and formulation optimization of solid lipid nanoparticles in vitamin K1 delivery, Drug Development and Industrial Pharmacy, 2010, 36(7), 751-761.

Ø   Liu, C. H., Wu, K. W. Synergistic effects of basic fibroblast growth factor and insulin on Chinese hamster ovary cells under serum-free conditions, 2009, J. Bioscience and Bioengineering, 107(3), 312-317.

國際研討會論文

Ø   Tsao, M.H., Sahoo, S.L., Liu, C.H., DNA staining nanoparticles for nucleus imaging, 2016 Society for Biotechnology Japan, Toyama, Japan, 2016, Sep 28-Oct 2.

Ø   Lee, W.S. Rout, B., Liu, C.H., Photodynamic antibacterial activity of curcumin by nano-lipid vehicles, 2015 Society for Biotechnology Japan, Kagoshima, Japan, 2015, Oct 26-28.

Ø   Rout, B., Liu, C.H., Photodynamic antibacterial effect of Toluidine Blue O and EDTA in a microemulsion delivery system, Symposium of Young Asian Biochemical Engineer’s Community, Chuncheon, Korea, 2015, Oct 15-16.

Ø   Chen Y.J., Liu, C.H., Polyphenol ocular delivery by nanocarriers. Symposium of Young Asian Biochemical Engineer’s Community 2015, Chuncheon, Korea, 2015, Oct15-16.

Ø   Chi-Hsien Liu, Yu-Jui Chen, Yun-Chun Huang, Antioxidation and ocular delivery of quercetin laden lipid nanocarriers, 2014 annual meeting of the Society for Biotechnology, Japan. Sep, 9-11, 2014.

Ø   Chi-Hsien Liu, Min Han Tsao, Functional iron nanoparticles for cell labeling and    DNA separation, 2013 annual meeting of the Society for Biotechnology, Japan. Sep, 18-20, 2013.

Ø   Yu DS , Tsao SW and Hsu FY. Fabrication and characterization of Eudragit S100-coatedpectin/alginate microcapsules containing cisplatin-hyaluronan nanoparticles for colon targeted delivery. 40th Annual Meeting & Exposition of the Controlled Release Society, July. 2013, Hawaii, America

 

專利與成果

劉繼賢,賴宣余,吳為吉, 磁性粒子純化血液酵素, 中華民國專利申請中

劉繼賢,廖啟成, 2000 , 生產紅茶菇飲料之菌株及其用於發酵製備紅茶菇飲料之方法 (日本國專利特許第3084348) (中華民國專利編號385335)

Optimizing culture medium for CD34+ hematopoietic cell expansion. 2014,

專利號碼: US 8,762,074 B2 發明人:黃效民、劉繼賢、姚少凌、朱一民、謝祖柏